merck millipore,默克密理愽
  • merck millipore,默克密理博,681665,Wnt Agonist - CAS 853220-52-7 - Calbiochem

  • merck millipore,默克密理博,681665,Wnt Agonist - CAS 853220-52-7 - Calbiochem

    产品名称：Wnt Agonist - CAS 853220-52-7 - Calbiochem
    产品型号：681665
    The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,681665,Wnt Agonist - CAS 853220-52-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681665,Wnt Agonist - CAS 853220-52-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₈N₄O₃853220-52-7
    描述
    概述 A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
    产品目录编号 681665
    品牌系列 Calbiochem®
    同义词 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
    参考
    参考 Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
    产品信息
    CAS号 853220-52-7
    具有ATP竞争性 N
    形式 Yellowish sticky solid
    Hill配方 C₁₉H₁₈N₄O₃
    化学配方 C₁₉H₁₈N₄O₃
    Molar Mass 350.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Selective activator of Wnt signaling
    主靶IC50 EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681665,Wnt Agonist - CAS 853220-52-7 - Calbiochem

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