merck millipore,默克密理愽
  • merck millipore,默克密理博,676503,VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem

  • merck millipore,默克密理博,676503,VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem

    产品名称：VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem
    产品型号：676503
    The VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor controls the biological activity of VEGFR/Tie-2/PDGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati More>>

    merck millipore,默克密理博,676503,VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,676503,VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem

    重要规格表

    经验配方
    C₂₁H₁₅F₄N₅O₂
    描述
    概述 An orally bioavailable pyrrolopyrimidinylurea compound that simultaneously binds to both the adenine and the adjacent hydrophobic pocket of the inactive form of VEGFR2 with high-affinity (type-II inhibitor) and acts as a pseudo-irreversible inhibitor with prolonged action. Shown to potently inhibit the activities of VEGFR2, VEGFR1, Tie-2, PDGFRα, PDGFRβ and c-kit (IC50 = 6.2, 15, 20, 35, 96 and 170 nM, respectively) with moderate to excellent selectivity over B-raf and Aurora-A (IC50 = 0.9 and 1.05 µM) and FGFR1, HER2, EGFR, IR, PKCθ (> 10 µM) among 18-kinases. Arrests VEGF-induced HUVECs proliferation (IC50 = 4.4 µM) and suppresses DU145 carcinoma growth in a xenograft nude mouse model (6 mg/kg, b.i.d.).
    产品目录编号 676503
    品牌系列 Calbiochem®
    同义词 1-(2-Fluoro-4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea, VEGFR Tyrosine Kinase Inhibitor XXXIV, VEGFR2 Kinase Inhibitor XXXII, VEGFR1 Kinase Inhibitor VII, PDGFR Tyrosine Kinase Inhibitor XXI
    参考
    参考 Oguro, Y., et al. 2010. Bioorg. Med. Chem. 18, 7150.
    产品信息
    形式 Light beige solid
    Hill配方 C₂₁H₁₅F₄N₅O₂
    化学配方 C₂₁H₁₅F₄N₅O₂
    Molar Mass 445.4
    吸湿 Hygroscopic
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 monthst at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,676503,VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,551476,InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,CBL450F,Anti-ICAM-1 Antibody, clone 15.2, FITC conjugated


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