merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1086,Anti-TGF-beta Receptor Antibody, type I

  • merck millipore,默克密理博,06-1086,Anti-TGF-beta Receptor Antibody, type I

    产品名称：Anti-TGF-beta Receptor Antibody, type I
    产品型号：06-1086
    This Anti-TGF-beta Receptor Antibody, type I is validated for use in WB, IH(P) for the detection of TGF-beta Receptor.

    merck millipore,默克密理博,06-1086,Anti-TGF-beta Receptor Antibody, type I

  • 产品介绍
  • merck millipore,默克密理博,06-1086,Anti-TGF-beta Receptor Antibody, type I

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ca, H, M, Eq, R, Op, Po, BWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1086
    描述 Anti-TGF-beta Receptor Antibody, type I
    Alternate Names
    • Activin receptor-like kinase 5
    • TGF-beta receptor type-1
    • Transforming growth factor-beta receptor type I
    • TGF-beta receptor type I
    • TGF-beta type I receptor
    • Serine/threonine-protein kinase receptor R4
    背景信息 Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS) (Uniprot/Swissprot).
    产品信息
    格式 Affinity Purified
    控制
    • HepG2 cell lysate, mouse spleen tissue
    演示 Purified rabbit polyclonal in PBS with 0.06% sodium azide.
    应用
    应用 This Anti-TGF-beta Receptor Antibody, type I is validated for use in WB, IH(P) for the detection of TGF-beta Receptor.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry (paraffin) Analysis: A 1:100 dilution of a previous lot was used to detect TGF-beta receptor, type I in mouse spleen tissue.
    Optimal Staining With Citrate pH 6.0 Epitope Retrieval: Mouse Spleen
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of TGF-beta receptor, type-I.
    表位 Cytoplasmic Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Antibody recognizes the cytoplasmic domain of TGF-beta receptor, type-I.
    品种反应性 CanineHumanMouseHorseRatOpossumPigBovine
    Species Reactivity Note Demonstrated to react with human and mouse.
    Predicted to react with horse, rat, opossum, pig, bovine and canine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004293
    Entrez基因汇总 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq]
    基因符号
    • ALK-5
    • TbetaR-I
    • TGFBR1
    • TGFR-1
    • SKR4
    纯化方法 Affinity Purfied
    UniProt编号
    • P36897
    UniProt汇总 FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

    CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    COFACTOR: Magnesium or manganese.

    SUBUNIT STRUCTURE: Interacts with CD109 and RBPMS. The unphosphorylated protein interacts with FKBP1A and is stabilized the inactive conformation. Phosphorylation of the GS region abrogates FKBP1A binding. Interacts with SMAD2 when phosphorylated on several residues in the GS region.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICITY: Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.

    POST-TRANSLATIONAL MODIFICATION: Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region.

    INVOLVEMENT IN DISEASE: Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism, and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm with dissection throughout the arterial tree.

    Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 2A (LDS2A) [MIM:608967]. LDS2 is an aortic aneurysm syndrome with widespread systemic involvement. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, diffuse arterial aneurysms and dissections, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. LDS2 is characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present in some patients.

    Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.



    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

    Contains 1 GS domain.

    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HepG2 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected TGF-beta receptor, type I in 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1086,Anti-TGF-beta Receptor Antibody, type I

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