merck millipore,默克密理愽
  • merck millipore,默克密理博,AG909,ADAM 17, control peptide for AB19027

  • merck millipore,默克密理博,AG909,ADAM 17, control peptide for AB19027

    产品名称：ADAM 17, control peptide for AB19027
    产品型号：AG909


    merck millipore,默克密理博,AG909,ADAM 17, control peptide for AB19027

  • 产品介绍
  • merck millipore,默克密理博,AG909,ADAM 17, control peptide for AB19027

    描述
    产品目录编号 AG909
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 ADAM 17, control peptide for AB19027
    概述 The peptide is used for blocking the activity of anti-TACE, C-Terminal (Catalog number AB19027). Incubate the peptide with equal volume of antibody for 30 minutes at 37oC to block the activity of anti-TACE in Western blotting. Amino Acids 807 to 823 (ASFKLQRQNRVDSKETE) of human TACE (Black et al. 1997; Moss et al. 1997).
    Alternate Names
    • CD156b
    • TACE
    产品信息
    演示 Liquid in PBS containing 0.1% BSA and 0.02% sodium azide.
    应用
    主要应用
    • Peptide Inhibition Assay
    应用说明 For use in blocking the reactivity of AB19027.

    Optimal working dilution must be determined by the end user.
    生物信息
    浓缩 200 μg/mL
    品种 Human
    Entrez基因编号
    • NM_003183.4
    Entrez基因汇总 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
    基因符号
    • EC 3.4.24.86
    • ADAM17
    • MGC71942
    • cSVP
    • CSVP
    • CD156b
    • TACE
    • CD156B
    UniProt编号
    • P78536
    UniProt汇总 FUNCTION: SwissProt: P78536 # Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
    COFACTOR: Binds 1 zinc ion per subunit.
    SIZE: 824 amino acids; 93021 Da
    SUBUNIT: Interacts with MAD2L1.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
    DOMAIN: SwissProt: P78536 Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity). & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    PTM: The precursor is cleaved by a furin endopeptidase (By similarity). & Phosphorylated. Stimulation by growth factor or phorbol 12- myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
    SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AG909,ADAM 17, control peptide for AB19027

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