merck millipore,默克密理愽
  • merck millipore,默克密理博,MABD51,Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

  • merck millipore,默克密理博,MABD51,Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

    产品名称：Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2
    产品型号：MABD51
    Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2 detects level of Brn-2 (POU3F2) & has been published & validated for use in Western Blotting, IHC(P).

    merck millipore,默克密理博,MABD51,Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

  • 产品介绍
  • merck millipore,默克密理博,MABD51,Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABD51
    描述 Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2
    Alternate Names
    • OTF-7
    • POU domain, class 3, transcription factor 2
    • Brain-specific homeobox/POU domain protein 2
    • Brain-2
    • Brn-2
    • Nervous system-specific octamer-binding transcription factor N-Oct-3
    • Octamer-binding protein 7
    • Oct-7
    • Octamer-binding transcription factor 7
    背景信息 Brn-2 (POU domain, class 3, transcription factor 2; Oct-7; N-Oct-3; or POU3F2) is a member of a large family of POU-domain transcription factors. The highly homologous POU domain contains a POU-specific domain at the N-terminus, a POU-homeo domain at the C-terminus and an interconnecting linker region. The POU domain binds to the DNA sequence 5’-ATGCAAAT-3’. Brn-2 is highly expressed in the developing CNS and may play a role in neurogenesis, particularly in the development of the hypothalamus. Previous studies have also suggested that Brn-2 integrates signals downstream of the BRAF/MAP kinase and Wnt/β-catenin pathways, and Brn-2 may be involved in the transformation and proliferation of melanomas.
    产品信息
    格式 Purified
    控制
    • SK-N-MC cell lysates
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2 detects level of Brn-2 (POU3F2) & has been published & validated for use in Western Blotting, IHC(P).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Brn-2 in normal rat brain tissue, in Purkinje, basket, and glial cells of rat cerebellum tissue, in neurons of rat cerebellum tissue, in neurons and glial cells of rat frontal cortex tissue, and in neurons of human pons tissue.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding human Brn-2 (POU3F2).
    克隆 8C4.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 RatHuman
    Species Reactivity Note Demonstrated to react with Human and Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005595.2
    Entrez基因汇总 POU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 and Oct2 and the pituitary protein Pit. Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.
    基因符号
    • OTF7
    • POU3F2
    • BRN2
    • OCT7
    纯化方法 Protein G purified
    UniProt编号
    • P20265
    UniProt汇总 FUNCTION: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters.

    SUBUNIT STRUCTURE: Interacts with PQBP1.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Expressed specifically in the neuroectodermal cell lineage.
    产品使用声明
    质量保证 Evaluated by Western Blot in SK-N-MC cell lysates.

    Western Blot Analysis: A 1:2,000 dilution of this antibody detected Brn-2 (POU3F2) in 10 µg of SK-N-MC cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABD51,Anti-Brn-2 (POU3F2) Antibody, clone 8C4.2

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