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经验配方 CAS号 C₁₀H₆N₂O₂ 118409-57-7 描述 概述 A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. 产品目录编号 658395 品牌系列 Calbiochem®
同义词 α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810 参考 参考 Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
Williams, J.A. 1994. Am. J. Physiol. 267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.产品信息 CAS号 118409-57-7 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₀H₆N₂O₂ 化学配方 C₁₀H₆N₂O₂ Molar Mass 186.2 可逆 N 结构配方图像 生物信息 主靶 epidermal growth factor receptor autophosphorylation 主靶IC50 40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 溶解度 Acetic acid, DMSO, or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
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