merck millipore,默克密理愽
  • merck millipore,默克密理博,651070,Tubulysin A, Myxobacteria sp. - Calbiochem

  • merck millipore,默克密理博,651070,Tubulysin A, Myxobacteria sp. - Calbiochem

    产品名称：Tubulysin A, Myxobacteria sp. - Calbiochem
    产品型号：651070
    A cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative as well as antiangiogenic properties.

    merck millipore,默克密理博,651070,Tubulysin A, Myxobacteria sp. - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,651070,Tubulysin A, Myxobacteria sp. - Calbiochem

    重要规格表

    经验配方
    C₄₃H₆₅N₅O₁₀S
    描述
    概述 A cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative (average of estimated GI50 ~ 12 nM in the NCI 60-human cancer cell line panel) as well as antiangiogenic (IC50 = 2.07 and 2.97 nM in inhibiting HUVEC cord junctions and length, respectively) properties. Shown to be efficacious in hollow fiber assays in mice in vivo and exhibit excellent cancer selectivity (100% and 0% apotosis induction at 10 nM in HL-60 and HUVEC cells, respectively) in vitro.
    产品目录编号 651070
    品牌系列 Calbiochem®
    同义词 tubA
    参考
    参考 Kaur, G., et al. 2006. Biochem. J. 396, 235.
    Steinmetz, H., et al. 2004. Angew. Chem. 43, 4888.
    Sasse, F., et al. 2000. J. Antibiot. 53, 879.
    产品信息
    具有ATP竞争性 N
    声明 Licensed from Helmholtz Centre for Infection Research (former GBF) in Braunschweig, Germany.
    形式 White solid
    Hill配方 C₄₃H₆₅N₅O₁₀S
    化学配方 C₄₃H₆₅N₅O₁₀S
    Molar Mass 844.1
    可逆 N
    结构配方图像
    生物信息
    主靶 Anti-microtubule agent
    主靶IC50 2.07 and 2.97 nM in inhibiting HUVEC cord junctions and length, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,651070,Tubulysin A, Myxobacteria sp. - Calbiochem

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