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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB4500 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-B23 Antibody, clone 3C9 Alternate Names - Nucleophosmin
背景信息 B23/Nucleophosmin is a major nucleolar phosphoprotein that is mainly located within the nucleolar granular compartment, where preribosomes are assembled. B23/Nucleophosmin is a multifunctional protein that is overexpressed in actively proliferating cells and cancer cells. Antibodies against B23 might be useful for recognition of human peripheral lymphocytes at early stages of their activation for proliferation, preceding the S-phase (Dergunova, 2002). By parallel immunolabeling with the anti-Ki-67 antibody, it was shown that the early changes of B23 amount and localization occurred before an appearance of Ki-67 protein, a well-known marker of proliferating cells (Dergunova, 2002). 产品信息 格式 Purified 演示 0.05M Potassium phosphate, 0.3M Sodium chloride, and 0.05% Sodium azide 应用 应用 Anti-B23 Antibody, clone 3C9 is an antibody against B23 for use in IF, IP & WB. 主要应用 - Western Blotting
应用说明 Western blot
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Total extracts of Daudi cell nuclei. 克隆 3C9 宿主 Mouse 特异性 Recognizes human Nucleophosmin (B23). 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_199185.2
- NM_001037738.1
- NM_002520.5
基因符号 - B23
- NPM1
- Numatrin
- numatrin
- Nucleophosmin
- MGC104254
- NPM
UniProt编号 - P06748
UniProt汇总 FUNCTION: SwissProt: P06748 # Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome.
SIZE: 294 amino acids; 32575 Da
SUBUNIT: Disulfide-linked dimers under certain conditions. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2.
SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML.
PTM: Phosphorylated.
DISEASE: SwissProt: P06748 # A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. & A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA. & A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1. & Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location.
SIMILARITY: SwissProt: P06748 ## Belongs to the nucleoplasmin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up 12 months from date of receipt. 包装信息 数量 100 µg
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