merck millipore,默克密理愽
  • merck millipore,默克密理博,189410,Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

  • merck millipore,默克密理博,189410,Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

    产品名称：Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem
    产品型号：189410
    The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation  More>>

    merck millipore,默克密理博,189410,Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,189410,Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₉H₃₁N₅O₄331771-20-1
    描述
    概述 A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
    产品目录编号 189410
    品牌系列 Calbiochem®
    同义词 4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
    参考
    参考 Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
    Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
    产品信息
    CAS号 331771-20-1
    形式 White solid
    Hill配方 C₂₉H₃₁N₅O₄
    化学配方 C₂₉H₃₁N₅O₄
    Molar Mass 513.6
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,189410,Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MAB4500,Anti-B23 Antibody, clone 3C9


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