merck millipore,默克密理愽
  • merck millipore,默克密理博,565791,γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem

  • merck millipore,默克密理博,565791,γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem

    产品名称：γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem
    产品型号：565791
    The γ-Secretase Inhibitor XXII, Aβ42-Selective, CS-1, also referenced under CAS 1210283-33-2, controls the biological activity of γ-Secretase.

    merck millipore,默克密理博,565791,γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565791,γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₁₃F₃O₆1210283-33-2
    描述
    概述 A cell-permeable di-coumarin compound that selectively inhibits γ-secretase-mediated production of Aβ42 over Aβ38, Aβ40, and Notch1 both in cell-free APP cleavage assays (IC50 = 0.07, 0.71, 0.31, and 1.77 µM, respectively) and in human and murine cultures (100% blockage of Aβ42 production and no effect against the rest at 30 µM) by altering the S1' and S3' pockets within the presenilin substrate binding site via an allosteric, non-substrate-competitive mechanism.
    产品目录编号 565791
    品牌系列 Calbiochem®
    同义词 3,3ʹ-(3,4,5-Trifluorophenyl)methylenebis-(4-hydroxycoumarin)
    参考
    参考 Shelton, C.C., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 20228.
    产品信息
    CAS号 1210283-33-2
    形式 White solid
    Hill配方 C₂₅H₁₃F₃O₆
    化学配方 C₂₅H₁₃F₃O₆
    Molar Mass 466.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565791,γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem

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