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经验配方 CAS号 C₁₅H₁₇ClFNO₄S 243984-11-4 描述 概述 A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9 nM, respectively, against LPS-induced NO, IL-6, and TNF-α production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7 mg/kg, i.p.) induced death in mice (3 mg/kg; i.v.) in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508336). 产品目录编号 614316 品牌系列 Calbiochem®
同义词 Ethyl-(6R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 参考 参考 Matsunaga, N., et al. 2011. Mol. Pharmacol. 79, 34.
Takashima, K., et al. 2009. Br. J. Pharmacol. 157, 1250.
Li, M., et al. 2006. Mol. Pharmacol. 69, 1288.
Yamada, M., et al. 2005. J. Med. Chem. 48, 7457.产品信息 CAS号 243984-11-4 形式 Yellowish white solid Hill配方 C₁₅H₁₇ClFNO₄S 化学配方 C₁₅H₁₇ClFNO₄S Molar Mass 361.8 可逆 Y 结构配方图像 生物信息 主靶 TLR4 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 安全信息 R相 R: 22
Harmful if swallowed.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 year at -70°C. Use only fresh DMSO. 包装信息 惰性气体下包装 Packaged under inert gas
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