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- 体外诊断/OEM材料和试剂
- 产品介绍
描述 产品目录编号 CBL260-K 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Macrophages, clone MAC387 (1mg) 概述 This product is intended for use by IVD manufacturers. 产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg(1ml) in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Suitable for use on formalin-fixed paraffin sections. As seen with other macrophage markers CBL 260 is not totally macrophage specific and should be used in a panel of other antibodies.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human monocytes 克隆 MAC387 宿主 Mouse 特异性 Recognises the L1 or Calprotectin molecule, an intracytoplasmic antigen comprised of a 12kD a- chain and a 14kDa β-chain. The antigen is expressed by granulocytes, monocytes, tissue macrophages, neutrophils and squamous mucosal epithelia.
KNOWN SPECIES CROSS REACTIVITY: Cross reacts with baboon, cat, dog, guinea pig, horse, monkey, rabbit, rat and swine.
FUSION PARTNER: NS1 myeloma cell line.同种型 IgG1 品种反应性 FelineCanineHorseGuinea PigHumanMonkeyPigRatRabbitBaboon 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002964.3
Entrez基因汇总 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. 基因符号 - P8
- S100A8
- CFAG
- Calgranulin-A
- 60B8AG
- MRP8
- CGLA
- L1Ag
- MIF
- MRP-8
- MA387
- CAGA
- CP-10
- NIF
UniProt编号 - P05109
UniProt汇总 FUNCTION: SwissProt: P05109 # Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.
SIZE: 93 amino acids; 10835 Da
SUBUNIT: Homodimer.
SIMILARITY: SwissProt: P05109 ## Belongs to the S-100 family. & Contains 2 EF-hand domains.
MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 Bulk packaging. Please inquire.
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