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  • merck millipore,默克密理博,07-972,Anti-phospho-HP1 γ (Ser83) Antibody

  • merck millipore,默克密理博,07-972,Anti-phospho-HP1 γ (Ser83) Antibody

    产品名称：Anti-phospho-HP1 γ (Ser83) Antibody
    产品型号：07-972
    Anti-phospho-HP1 γ (Ser83) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-HP1 γ (Ser83) also known as Heterochromatin protein 1 homolog gamma, HECH & has been validated in WB.

    merck millipore,默克密理博,07-972,Anti-phospho-HP1 γ (Ser83) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-972,Anti-phospho-HP1 γ (Ser83) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-972
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-HP1 γ (Ser83) Antibody
    Alternate Names
    • HECH
    • Chromobox protein homolog 3
    • Heterochromatin protein 1 homolog gamma
    • Modifier 2 protein
    产品信息
    格式 Purified
    演示 Immunoaffinity purified rabbit IgG in PBS containing 30% glycerol.
    应用
    应用 Anti-phospho-HP1 γ (Ser83) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-HP1 γ (Ser83) also known as Heterochromatin protein 1 homolog gamma, HECH & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Phosphopeptide corresponding to amino acid position 76-88 (DGTKRKpSLSDSE-88) of human HP1 gamma.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 HP1γ phosphorylated at Ser83.
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_016587.2
    • NM_007276.3
    Entrez基因汇总 At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
    基因符号
    • HECH
    • CBX3
    • HP1-GAMMA
    • HP1Hs-gamma
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q13185
    UniProt汇总 FUNCTION: SwissProt: Q13185 # Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
    SIZE: 183 amino acids; 20811 Da
    SUBUNIT: Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A (By similarity). Interacts with MIS12 and C20orf127. Can interact directly with CBX5 via the chromoshadow domain.
    SUBCELLULAR LOCATION: Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
    PTM: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
    SIMILARITY: SwissProt: Q13185 ## Contains 2 chromo domains.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-972,Anti-phospho-HP1 γ (Ser83) Antibody

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