merck millipore,默克密理愽
  • merck millipore,默克密理博,613550,TMEM16A Activator, Eact - Calbiochem

  • merck millipore,默克密理博,613550,TMEM16A Activator, Eact - Calbiochem

    产品名称：TMEM16A Activator, Eact - Calbiochem
    产品型号：613550
    The TMEM16A Activator, Eact modulates the biological activity of TMEM16A. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,613550,TMEM16A Activator, Eact - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,613550,TMEM16A Activator, Eact - Calbiochem

    重要规格表

    经验配方
    C₂₂H₂₄N₂O₅S
    描述
    概述 An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50 = 3 µM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10 µM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance.
    产品目录编号 613550
    品牌系列 Calbiochem®
    同义词 ANO1 Activator, Eact, 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide, TMEM16A Activator, Eact
    参考
    参考 Namkung, W., et al. 2011. FASEB J. 25, 4048.
    产品信息
    形式 White powder
    Hill配方 C₂₂H₂₄N₂O₅S
    化学配方 C₂₂H₂₄N₂O₅S
    Molar Mass 428.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,613550,TMEM16A Activator, Eact - Calbiochem

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