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  • merck millipore,默克密理博,07-845,Anti-phospho-IRS1 (Tyr1229) Antibody

  • merck millipore,默克密理博,07-845,Anti-phospho-IRS1 (Tyr1229) Antibody

    产品名称：Anti-phospho-IRS1 (Tyr1229) Antibody
    产品型号：07-845
    anti-phospho-IRS1 (Tyr1229) Antibody detects level of phospho-IRS1 (Tyr1229) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-845,Anti-phospho-IRS1 (Tyr1229) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-845,Anti-phospho-IRS1 (Tyr1229) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-845
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-IRS1 (Tyr1229) Antibody
    Alternate Names
    • IRS-1, Insulin Receptor Substrate-1
    • IRS-1
    产品信息
    格式 Purified
    演示 100 μL of affinity purified rabbit polyclonal IgG in buffer (PBS (without Mg2+ and Ca2+), pH 7.4 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide).
    应用
    应用 anti-phospho-IRS1 (Tyr1229) Antibody detects level of phospho-IRS1 (Tyr1229) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Immunoblot Analysis: 0.5 μg/mL of this lot detected phospho-IRS1 (Tyr1229) in RIPA lysates from insulin treated IRS1 transfected CHO cells.
    生物信息
    免疫原品种 Peptide corresponding to the amino acid region encompassing the human phospho-IRS1(Tyr1229). Sequence highly conserved in mouse and rat.
    宿主 Rabbit
    特异性 Human IRS1 (Insulin Receptor Substrate 1) phosphorylated on Tyrosine residue 1229. Sequence highly homologous with mouse and rat, but have not been tested.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note May cross-react with mouse and rat (based on sequence homology), but have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005544.1
    基因符号
    • HIRS-1
    • IRS1
    • IRS-1
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P35568
    UniProt汇总 FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
    SIZE: 1242 amino acids; 131591 Da
    SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
    PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
    SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -80°C.
    Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-845,Anti-phospho-IRS1 (Tyr1229) Antibody

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