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merck millipore,默克密理博,586005,Thapsigargin - CAS 67526-95-8 - Calbiochem
产品名称：Thapsigargin - CAS 67526-95-8 - Calbiochem
产品型号：586005
A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC₅₀ = 4-13 nM).
merck millipore,默克密理博,586005,Thapsigargin - CAS 67526-95-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₄H₅₀O₁₂ 67526-95-8 描述 概述 A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation. 产品目录编号 586005 品牌系列 Calbiochem®
参考 参考 Jothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.产品信息 CAS号 67526-95-8 具有ATP竞争性 N 形式 Colorless solid Hill配方 C₃₄H₅₀O₁₂ 化学配方 C₃₄H₅₀O₁₂ Molar Mass 650.8 可逆 N 结构配方图像 生物信息 主靶 endoplasmic reticular Ca2+ ATPase 主靶IC50 4-13 nM against endoplasmic reticular Ca2+-ATPase 纯度 ≥97% by TLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38-42
Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation.S相 S: 36/37/39-26
Wear suitable protective clothing, gloves and eye/face protection.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
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