- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,05-862,Anti-Plasminogen/Angiostatin Antibody, clone GMA-013
产品名称：Anti-Plasminogen/Angiostatin Antibody, clone GMA-013
产品型号：05-862
This Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 is validated for use in ELISA, WB for the detection of Plasminogen/Angiostatin.
merck millipore,默克密理博,05-862,Anti-Plasminogen/Angiostatin Antibody, clone GMA-013
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 05-862 品牌系列 Upstate
商名 - Upstate
描述 Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 产品信息 格式 Purified 应用 应用 This Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 is validated for use in ELISA, WB for the detection of Plasminogen/Angiostatin. 主要应用 - Western Blotting
- ELISA
生物信息 免疫原品种 Purified human plasminogen 克隆 clone GMA-013 宿主 Mouse 特异性 Plasminogen (kringles 1-3) 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000301
Entrez基因汇总 Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase (PLAU; MIM 191840) and tissue plasminogen activator (TPA, PLAT; MIM 173370). The main function of plasmin is to dissolve fibrin (see, e.g., FGA, MIM 134820) clots. Plasmin, like trypsin, belongs to the family of serine proteinases (Miyata et al., 1982 [PubMed 6216475]; Forsgren et al., 1987 [PubMed 3030813]).[supplied by OMIM] 基因符号 - plasminogen
- PLG
- DKFZp779M0222
纯化方法 DEAE purified UniProt编号 - P00747
UniProt汇总 FUNCTION: SwissProt: P00747 # Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
SIZE: 810 amino acids; 90569 Da
SUBUNIT: Interacts with AMOT and CSPG4 (also true for angiostatin).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Present in plasma and many other extracellular fluids. It is synthesized in the kidney.
DOMAIN: SwissProt: P00747 Kringle domains mediate interaction with CSPG4.
PTM: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). & In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
DISEASE: "SwissProt: P00747 # Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis. & Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed ""ligneous"" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract."
SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. & Contains 5 kringle domains. & Contains 1 PAN domain. & Contains 1 peptidase S1 domain.
MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.产品使用声明 质量保证 routinely evaluated by immunoblot on human plasminogen 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable 2 years at -20°C from date of shipment 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,30-055,Protease Substrate Set
下一件merck millipore产品：merck millipore,默克密理博,AB2290,Anti-MAP-2 Antibody
相关产品
merck millipore,默克密理博,344847,Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem
merck millipore,默克密理博,HTS074RTA,Ready-to-Assay™ PK1 Prokinecticin Receptor Frozen Cells
merck millipore,默克密理博,539053,Protein Molecular Weight Markers, HPLC
merck millipore,默克密理博,ABS433,Anti-IL-32 Antibody
merck millipore,默克密理博,30-055,Protease Substrate Set
merck millipore,默克密理博,AB2290,Anti-MAP-2 Antibody
merck millipore,默克密理博,AB9218,Anti-Collapsin Response Mediator Protein 2 Antibody
merck millipore,默克密理博,MAB3424-K,Anti-Bromodeoxyuridine, Clone Ah4H7-1 / 131-14871
merck millipore,默克密理博,586005,Thapsigargin - CAS 67526-95-8 - Calbiochem
merck millipore,默克密理博,16-217,Anti-TNFα Antibody, clone 3B8, biotin conjugate, mouse