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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2290 Replaces AB5622 描述 Anti-MAP-2 Antibody Alternate Names - MAP 2
- microtubule-associated protein 2
- MAP2
背景信息 The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurons. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules. 产品信息 格式 Affinity Purified 控制 - Rat brain microsomal tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MAP-2 Antibody is an antibody against MAP-2 for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:200 dilution from a previous lot detected MAP-2 in rat brain tissue. 生物信息 免疫原品种 Three KLH-conjugated linear peptides corresponding to the N-terminal and central regions of rat MAP-2 . 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes MAP-2. 品种反应性 Rat Species Reactivity Note Demonstrated to react with rat.
Other homologies: Mouse (94% sequence homology). Human (72% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_037198
Entrez基因汇总 Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD]. 基因符号 - MAP2A
- MAP2
- MAP2B
- MAP-2
- MAP2C
纯化方法 Affinity purified UniProt编号 - P15146
UniProt汇总 FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable.
DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). MAP2A/c is phosphorylated.
SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.产品使用声明 质量保证 Evaluated by Western Blot in rat brain microsomal tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected MAP-2 on 10 µg of rat brain microsomal tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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