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merck millipore,默克密理博,573110,STAT5 Inhibitor III, Pimozide - CAS 2062-78-4 - Calbiochem
产品名称：STAT5 Inhibitor III, Pimozide - CAS 2062-78-4 - Calbiochem
产品型号：573110
The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>
merck millipore,默克密理博,573110,STAT5 Inhibitor III, Pimozide - CAS 2062-78-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₈H₂₉F₂N₃O 2062-78-4 描述 概述 A cell-permeable and orally available diphenylbutylpiperidine class of psychotropic drug with antagonistic activity against DAT (dopamine transporter) as well as several postsynaptic receptors, including D1, D2, D3, D4, α1-/α2-adrenergic, and 5-HT2A receptors. In addition to its antipsychotic property, Pimozide is shown to inhibit the constitutive STAT5 Tyr694 phosphorylation (5 to 10 µM for 3h) and transcription activity (5 µM for 18 h) in Bcr-Abl+ K562 and KU812 cultures, while exhibiting little activity against IFNα-stimulated STAT1 phosphorylation or LIF-stimulated STAT3 phosphorylation in K562 cells (10 µM 1 h pretreatment). The mechanism of STAT5 inhibition is currently unknown and Primozide is reported to exhibit little inhibitory activity against cellular Bcr-Abl autophosphorylation or the kinase activities of Abl1 (Wt & T315I), Hck, Lyn A/B, and Src (≤7%) in cell-free kinase assays. Shown to exhibit selective antiproliferative activity against K562, KU812, and primary bone marrow mononuclear cells from CML patients (by >80%; 10 µM for 48 h), but not peripheral blood mononuclear cells from healthy individuals, due to G0/G1 cell cycle arrest and apoptosis induction. 产品目录编号 573110 品牌系列 Calbiochem®
同义词 1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one 参考 参考 Chen, J., et al. 2011. Chem. Biol 18, 1390.
Nelson, E.A., et al. 2011. Blood 117, 3421.产品信息 CAS号 2062-78-4 形式 White solid Hill配方 C₂₈H₂₉F₂N₃O 化学配方 C₂₈H₂₉F₂N₃O Molar Mass 461.6 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions ar stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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