merck millipore,默克密理愽
  • merck millipore,默克密理博,07-758,Anti-phospho-Flt-1 (Tyr1213) Antibody

  • merck millipore,默克密理博,07-758,Anti-phospho-Flt-1 (Tyr1213) Antibody

    产品名称：Anti-phospho-Flt-1 (Tyr1213) Antibody
    产品型号：07-758
    Anti-phospho-Flt-1 (Tyr1213) Antibody detects level of phospho-Flt-1 (Tyr1213) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-758,Anti-phospho-Flt-1 (Tyr1213) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-758,Anti-phospho-Flt-1 (Tyr1213) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sh, B, Gt, H, M, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-758
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Flt-1 (Tyr1213) Antibody
    Alternate Names
    • Fms-like tyrosine kinase
    • Vascular endothelial growth factor receptor 1 (VEGFR-1)
    • Vascular permeability factor receptor
    • Tyrosine-protein kinase FRT
    产品信息
    格式 Affinity Purified
    控制
    • Recombinant Flt-1 (Catalogue No. 14-562) phosphorylated by ATP
    演示 Immunoaffinity purified rabbit IgG in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
    应用
    应用 Anti-phospho-Flt-1 (Tyr1213) Antibody detects level of phospho-Flt-1 (Tyr1213) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide containing the sequence (...VR[pY]VN...) in which [pY] corresponds to phospho-tyrosine at residue 1213 of human Flt-1. The immunizing sequence is identical in marmoset, has 14/15 identical amino acids in rat, goat, sheep, cow, and rhesus monkey and 13/15 identical amino acids in mouse.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes phospho-Flt-1 (Tyr1213).
    同种型 IgG
    品种反应性 SheepBovineGoatHumanMouseRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002019.2
    Entrez基因汇总 Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]
    基因符号
    • VEGFR-1
    • FLT1
    • VEGFR1
    • FLT
    • FRT
    • Flt-1
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P17948
    UniProt汇总 FUNCTION: SwissProt: P17948 # Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
    SIZE: 1338 amino acids; 150769 Da
    SUBUNIT: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
    SUBCELLULAR LOCATION: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. & Isoform sFlt1: Secreted.
    TISSUE SPECIFICITY: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
    SIMILARITY: SwissProt: P17948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on recombinant Flt-1 (Catalog # 14-562) phosphorylated upon incubation with ATP
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-758,Anti-phospho-Flt-1 (Tyr1213) Antibody

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