merck millipore,默克密理博,572632,SU5614 - CAS 186611-56-3

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Merck Millipore 默克密理愽

merck millipore,默克密理博,572632,SU5614 - CAS 186611-56-3 - Calbiochem

经验配方	CAS号
C₁₅H₁₃N₂OCl	186611-56-3

描述
概述	A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC₅₀ = 1.2 µM) and PDGF (IC₅₀ = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC₅₀ ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
产品目录编号	572632
品牌系列	Calbiochem®
同义词	5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX

参考
参考	Cools, J., et al. 2004. Cancer Res. 64, 6385. Sun, L., et al. 1998. J. Med. Chem. 41, 2588.

产品信息
CAS号	186611-56-3
具有ATP竞争性	Y
声明	Not available for sale in the United States.
形式	Orange-red solid
Hill配方	C₁₅H₁₃N₂OCl
化学配方	C₁₅H₁₃N₂OCl
Molar Mass	272.7
可逆	Y
结构配方图像

生物信息
主靶	VEGF Flk-1
主靶IC₅₀	1.2 µM, 2.9 µM against VEGF (Flk-1) and PDGF receptor tyrosine kinases, respectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs)
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

merck millipore,默克密理博,572632,SU5614 - CAS 186611-56-3 - Calbiochem

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