merck millipore,默克密理博,217691,CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,217691,CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem

经验配方	CAS号
C₁₉H₂₅N₃O₄	396073-89-5

描述
概述	A cell-permeable ortho-hydroxybenzylamino compound that displays antitumor properties. Acts as a potent, selective and irreversible inhibitor of CDC25 phosphatase family (IC₅₀ = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Displays ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Shown to delay cell cycle progression in vitro (IC₅₀ = ~7.2-32.6 µM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
产品目录编号	217691
品牌系列	Calbiochem®
同义词	N-(2-Hydroxy-3-methoxy-5-dimethylamino)benzyl, Nʹ-(2-(4-nitrophenethyl)), Nʹʹ-methylamine, PTP Inhibitor XX

参考
参考	Brezak, M.C., et al. 2004. Cancer Res. 64, 3320.

生物信息
主靶	CDC25A
主靶IC₅₀	2.4, 3.9, 6.3, 5.4, and 4.6 µM for CDC25 phosphatase family 25A, 25B2, 25B3, 25C, and 25C-cat, respectively
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,217691,CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem

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