merck millipore,默克密理博,567860,SRT1720 - CAS 925434-55-5

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

merck millipore,默克密理博,567860,SRT1720 - CAS 925434-55-5 - Calbiochem
产品名称：SRT1720 - CAS 925434-55-5 - Calbiochem
产品型号：567860

merck millipore,默克密理博,567860,SRT1720 - CAS 925434-55-5 - Calbiochem

merck millipore,默克密理博,567860,SRT1720 - CAS 925434-55-5 - Calbiochem

经验配方	CAS号
C₂₅H₂₃N₇O_S	925434-55-5

描述
概述	A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (K_i = 0.56 µM; K_m = 2.44 µM), but NAD⁺-uncompetitive (K_i = 0.34 µM; K_m = 280 µM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 µM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC₅₀ = 9 µM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).
产品目录编号	567860
品牌系列	Calbiochem®
同义词	N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720, SIRT3 Inhibitor II, HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX

参考
参考	Baur, J.A., et al. 2012. Nat. Rev. Drug Discov. 11, 443. Minor, R.K., et al. 2011. Sci. Rep. 1, 70. Huber, J.L., et al. 2010. Future Med. Chem. 2, 1751 Pacholec, M., et al. 2010. J. Biol. Chem. 285, 8340 Jin, L., et al. 2009. Protein Sci. 18, 514 Feige, J.N., et al. 2008. Cell Metab. 8, 347 Milne, J.C., et al. 2007. Nature 450, 712.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,567860,SRT1720 - CAS 925434-55-5 - Calbiochem

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech