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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5603 Replaces AB5770 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sox2 Antibody 背景信息 SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. 产品信息 格式 Affinity Purified 控制 - Immunoblot: Mouse or human embryonic stem cell lysate, mouse embryonic germ cell lysate
Immunocytochemistry: Human embryonic stem cells (H9 line)
演示 Affinity Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH7.4. 应用 应用 Anti-Sox2 Antibody is an antibody against Sox2 for use in IC & WB. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Western blot: 2.0 µg/mL of this antibody detected Sox2 RBX in 10 µg of mouse embryonic stem cell lysate.
Immunocytochemistry: A 1:100 dilution from a representative lot detected SOX 2, RBX in H9 stem cells. Alexa Fluor® is a registered trademark of Life Technologies®.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Sox2 RBX. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Sox2 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003106.2
Entrez基因汇总 This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). 基因符号 - MCOPS3
- SOX2
- ANOP3
- MGC2413
纯化方法 Immunoaffinity purified UniProt编号 - P48431
UniProt汇总 FUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).
SIZE: 317 amino acids; 34310 Da
SUBCELLULAR LOCATION: Nucleus.
DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.
SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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