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merck millipore,默克密理博,539620,PP2A Inhibitor II, GST-Fusion, Human, Recombinant, E. coli - Calbiochem
产品名称：PP2A Inhibitor II, GST-Fusion, Human, Recombinant, E. coli - Calbiochem
产品型号：539620
The PP2A Inhibitor I, GST-Fusion, Human, Recombinant, E. coli controls the biological activity of PP2A. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation a More>>
merck millipore,默克密理博,539620,PP2A Inhibitor II, GST-Fusion, Human, Recombinant, E. coli - Calbiochem
- 产品介绍
- merck millipore,默克密理博,539620,PP2A Inhibitor II, GST-Fusion, Human, Recombinant, E. coli - Calbiochem
重要规格表
描述 概述 Recombinant, human PP2AI I2 fused to GST and expressed in E. coli. Inhibits protein phosphatase 2A (PP2A) potently with Ki ~ 25-30 nM with myelin basic protein, histone H1, and other substrates of PP2A but not with casein as a substrate. Stimulates PP1. Prevents inhibition of E-Cdk-2 by p21Cip1. Associates with B cyclin. Regulates histone binding to DNA, transcriptional activity and chromatin condensation. Undergoes phosphorylation in cells. Highly expressed in some cancers. Associates with HRX leukemia-associated fusion proteins. Occurs as fusion protein in acute undifferentiated leukemia. Does not inhibit PP1, PP2B, PP2C, or pyruvate dehydrogenase. 产品目录编号 539620 品牌系列 Calbiochem®
同义词 Protein Phosphatase 2A Inhibitor II, I₂PP2A 参考 参考 Li, M., et al. 1996. Biochemistry 35, 6998.
Li, M., et al. 1995. Biochemistry 34, 1988.产品信息 具有ATP竞争性 N 形式 Liquid 配方 In 50 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol, pH 7.4. Molar Mass 67000 可逆 N 生物信息 主靶 PP2A 主靶Ki ~ 25-30 nM 纯度 ≥90% by SDS-PAGE 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 细胞可渗透 N 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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