• merck millipore,默克密理博,526520,PIM1 Inhibitor II
  • merck millipore,默克密理博,526520,PIM1 Inhibitor II

    产品名称:PIM1 Inhibitor II
    产品型号:526520
    The PIM1 Inhibitor II, also referenced under CAS 491871-58-0, controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>

    merck millipore,默克密理博,526520,PIM1 Inhibitor II

  • 产品介绍
  • merck millipore,默克密理博,526520,PIM1 Inhibitor II

    重要规格表

    经验配方 CAS号
    C₁₈H₁₁BrN₂O₂491871-58-0
    描述
    概述 A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 > 20 µM).
    产品目录编号 526520
    品牌系列 Calbiochem®
    同义词 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
    参考
    参考 Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.
    产品信息
    CAS号 491871-58-0
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₈H₁₁BrN₂O₂
    化学配方 C₁₈H₁₁BrN₂O₂
    Molar Mass 367.2
    可逆 N
    结构配方图像
    生物信息
    主靶 PIM1
    主靶IC50 50 nM against PIM1 kinase
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,526520,PIM1 Inhibitor II

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