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经验配方 CAS号 C₃₀H₄₀O₄ 1258-84-0 描述 概述 A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50 = 2.2 and 3.0 µM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC50 ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50 = 93 nM). 产品目录编号 530070 品牌系列 Calbiochem®
同义词 MAGL Inhibitor II, Monoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX 参考 参考 Lu, Z., et al. 2010. Mol. Cancer 9, 112.
King, A.R., et al. 2009. Chem. Biol. 16, 1045.
Tiedemann, R.E., et al. 2009. Blood 113, 4027.
Yang, H., et al. 2008. J. Cell. Biochem. 103, 234.
Wu, C.C., et al. 2005. Mol. Cancer Ther. 4, 1277.产品信息 CAS号 1258-84-0 形式 Red solid Hill配方 C₃₀H₄₀O₄ 化学配方 C₃₀H₄₀O₄ Molar Mass 464.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 S相 S: 20-24/25-36/37/39
When using do not eat or drink.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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