merck millipore,默克密理愽
  • merck millipore,默克密理博,528122,PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

  • merck millipore,默克密理博,528122,PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

    产品名称：PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem
    产品型号：528122
    The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryla More>>

    merck millipore,默克密理博,528122,PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528122,PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₆ClN₃O₄S₂593960-11-3
    描述
    概述 A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50 = 16, 19, 39 and 64 nM for p110γ, PI 4-KIIIβ, p110α and DNA-PK, respectively). Moderately inhibits p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC50 = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50 > 10 µM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250 nM.
    产品目录编号 528122
    品牌系列 Calbiochem®
    同义词 N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide
    参考
    参考 Miller, S., et al. 2010. Science 327, 1638.
    Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
    Toth, B., et al. 2006. J. Biol. Chem. 281, 36369.
    Knight, Z.A., et al. 2006. Cell 125, 733.
    产品信息
    CAS号 593960-11-3
    形式 Pale yellow solid
    Hill配方 C₁₄H₁₆ClN₃O₄S₂
    化学配方 C₁₄H₁₆ClN₃O₄S₂
    Molar Mass 389.9
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528122,PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

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