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merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
产品名称:PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
产品型号:540213
The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>
merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₅N₅O₆S 314291-83-3 描述 概述 A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation. 产品目录编号 540213 品牌系列 Calbiochem®
同义词 PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III 参考 参考 Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 7275. 产品信息 CAS号 314291-83-3 形式 Reddish solid Hill配方 C₂₁H₁₅N₅O₆S 化学配方 C₂₁H₁₅N₅O₆S Molar Mass 465.4 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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