• merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
  • merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem

    产品名称:PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
    产品型号:540213
    The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>

    merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₅N₅O₆S314291-83-3
    描述
    概述 A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.
    产品目录编号 540213
    品牌系列 Calbiochem®
    同义词 PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III
    参考
    参考 Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 7275.
    产品信息
    CAS号 314291-83-3
    形式 Reddish solid
    Hill配方 C₂₁H₁₅N₅O₆S
    化学配方 C₂₁H₁₅N₅O₆S
    Molar Mass 465.4
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,540213,PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem

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