merck millipore,默克密理愽
  • merck millipore,默克密理博,528112,PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

  • merck millipore,默克密理博,528112,PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

    产品名称：PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem
    产品型号：528112
    The PI 3-Kγ/CKII Inhibitor, also referenced under CAS 1138220-19-5, controls the biological activity of PI 3-Kγ/CKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryl More>>

    merck millipore,默克密理博,528112,PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528112,PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₈FNO₄S1138220-19-5
    描述
    概述 A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
    产品目录编号 528112
    品牌系列 Calbiochem®
    同义词 (5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
    参考
    参考 Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.
    产品信息
    CAS号 1138220-19-5
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₄H₈FNO₄S
    化学配方 C₁₄H₈FNO₄S
    Molar Mass 305.3
    可逆 N
    结构配方图像
    生物信息
    主靶 PI 3-Kγ/CKII
    主靶IC50 20 nM against PI 3-Kγ and CKII
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528112,PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,71023,TriEx™ Sf9 Cells - Novagen
下一件merck millipore产品：merck millipore,默克密理博,475864,MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem


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