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经验配方 CAS号 C₂₆H₃₇N₅O₅ 171235-71-5 描述 概述 A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC50 = 8.09 µM) and muscarinic receptor-stimulated (IC50 = 3.61 µM) sAAPα release in HEK 293 cells expressing M3 muscarinic receptors. A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579050) in DMSO is also available. 产品目录编号 579051 品牌系列 Calbiochem®
同义词 N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1 参考 参考 Slack, B.E., et al. 2001. Biochem. J. 357, 787.
Vincent, B., et al. 2001. J. Biol. Chem. 276, 37743.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Crowe, P.D., et al. 1995. J. Exp. Med. 181, 1205.
Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
Mohler, K.M., et al. 1994. Nature 370, 218.产品信息 CAS号 171235-71-5 具有ATP竞争性 N 声明 Manufactured exclusively by Peptides International, Louisville, Kentucky, USA. 形式 White solid Hill配方 C₂₆H₃₇N₅O₅ 化学配方 C₂₆H₃₇N₅O₅ Molar Mass 499.6 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 MMPs and TACE 主靶IC50 8.09 µM and 3.61 µM blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors, respectively 纯度 ≥97% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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