merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1936,Anti-Fibronectin Antibody, NT, clone 616

  • merck millipore,默克密理博,MAB1936,Anti-Fibronectin Antibody, NT, clone 616

    产品名称：Anti-Fibronectin Antibody, NT, clone 616
    产品型号：MAB1936
    Anti-Fibronectin Antibody, N-terminus, clone 616 detects level of Fibronectin & has been published & validated for use in IH, IP, RIA & WB.

    merck millipore,默克密理博,MAB1936,Anti-Fibronectin Antibody, NT, clone 616

  • 产品介绍
  • merck millipore,默克密理博,MAB1936,Anti-Fibronectin Antibody, NT, clone 616

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1936
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Fibronectin Antibody, NT, clone 616
    产品信息
    格式 Purified
    控制
    • Extracellular matrix in most tissue
    演示 Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
    应用
    应用 Anti-Fibronectin Antibody, N-terminus, clone 616 detects level of Fibronectin & has been published & validated for use in IH, IP, RIA & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blotting

    Immunoprecipitation

    RIA

    Immunohistochemistry

    For best results in tissue staining, use cryostat sections fixed with either acetone or 4% formaldehyde. Has not been tested on paraffin embedded tissue.

    Final working dilutions must be determined by end user.
    生物信息
    免疫原品种 Proteins secreted by cultured human embryonic fibroblasts.
    表位 N-terminus
    克隆 616
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with whole human fibronectin and many of its proteolytic fragments. Specifically recognizes the 29 kDa N-terminal fibrin- and heparin-binding domain by Western blotting with purified domain from two different sources.
    同种型 IgG3
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_054034.2
    • NM_212474.1
    • NM_212475.1
    • NM_212476.1
    • NM_212478.1
    • NM_212482.1
    • NM_002026.2
    Entrez基因汇总 This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
    基因符号
    • FINC
    • FN1
    • DKFZp686H0342
    • DKFZp686I1370
    • MSF
    • CIG
    • LETS
    • DKFZp686O13149
    • FN
    • DKFZp686F10164
    纯化方法 Protein A purfied
    UniProt编号
    • P02751
    UniProt汇总 FUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
    SIZE: 2386 amino acids; 262607 Da
    SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
    TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
    PTM: Sulfated.
    SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Long Term Storage - Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Short Term Storage - Maintain at 2–8°C with 0.1% sodium azide for 1-6 weeks. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1936,Anti-Fibronectin Antibody, NT, clone 616

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