merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4430,Anti-Piwi-like protein 2 Antibody, clone 87/3

  • merck millipore,默克密理博,MAB4430,Anti-Piwi-like protein 2 Antibody, clone 87/3

    产品名称：Anti-Piwi-like protein 2 Antibody, clone 87/3
    产品型号：MAB4430
    Use Anti-Piwi-like protein 2 Antibody, clone 87/3 (Mouse Monoclonal Antibody) validated in IHC to detect Piwi-like protein 2 also known as Hiwi-like, Miwi like, Cancer/testis antigen 80.

    merck millipore,默克密理博,MAB4430,Anti-Piwi-like protein 2 Antibody, clone 87/3

  • 产品介绍
  • merck millipore,默克密理博,MAB4430,Anti-Piwi-like protein 2 Antibody, clone 87/3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4430
    描述 Anti-Piwi-like protein 2 Antibody, clone 87/3
    Alternate Names
    • PIWIL-2
    • piwi-like 2 (Drosophila)
    • piwi-like 2
    • Hiwi-like
    • Miwi like
    • Cancer/testis antigen 80
    • Mili
    • MILI
    • mili
    背景信息 Piwi-like protein 2 (PIWIL2) is a member of the Argonaute family of proteins and play essential roles in stem-cell self-renewal, RNA silencing and translational regulation in various organisms. Piwi-like protein 2 is not present in normal cells (other than testicular), or in inflammatory tissues; however, it is present in almost all cancer cell types. Piwi-like protein 2 inhibits tumor cell growth when repressed and acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.
    产品信息
    格式 Purified
    控制
    • Colorectal adenocarcinoma tissue
    演示 Purified mouse monoclonal IgM containing PBS with 0.05% sodium azide.
    应用
    应用 Use Anti-Piwi-like protein 2 Antibody, clone 87/3 (Mouse Monoclonal Antibody) validated in IHC to detect Piwi-like protein 2 also known as Hiwi-like, Miwi like, Cancer/testis antigen 80.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:300 dilution of this antibody has been shown to detect Piwi-like protein 2 in prostatic adenocarcinoma and human testis tissue.
    生物信息
    免疫原品种 Linear peptide corresponding to human Piwi-like protein 2 at the N-terminus.
    表位 N-terminus
    克隆 87/3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes Piwi-like protein 2 at the N-terminus.
    同种型 IgM
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    Other homologies: Mouse (73% sequence homology).
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001129193
    Entrez基因汇总 PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM].
    基因符号
    • PIWIL2
    • HILI
    • PIWIL1L
    • CT80
    • Mili
    • MILI
    • mili
    纯化方法 Protein G purfied
    UniProt编号
    • Q8TC59
    UniProt汇总 FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate to similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).

    SUBUNIT STRUCTURE: Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 (By similarity).

    SUBCELLULAR LOCATION: Cytoplasm By similarity. Note: Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity).

    TISSUE SPECIFICITY: Expressed in adult testis and in most tumors.

    PTM: Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the argonaute family. Piwi subfamily.

    Contains 1 PAZ domain.

    Contains 1 Piwi domain.

    SEQUENCE CAUTION: The sequence BAA91558.1 differs from that shown. Reason: Erroneous initiation.

    The sequence BAB55155.1 differs from that shown. Reason: Erroneous termination at position 421. Translated as Arg.
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

    Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Piwi-like protein 2 in colorectal adenocarcinoma tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4430,Anti-Piwi-like protein 2 Antibody, clone 87/3

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