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merck millipore,默克密理博,527450,PKR Inhibitor - CAS 608512-97-6 - Calbiochem
产品名称：PKR Inhibitor - CAS 608512-97-6 - Calbiochem
产品型号：527450
The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,527450,PKR Inhibitor - CAS 608512-97-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₃H₈N₄OS 608512-97-6 描述 概述 An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451). 产品目录编号 527450 品牌系列 Calbiochem®
同义词 Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I 参考 参考 Zhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.产品信息 CAS号 608512-97-6 具有ATP竞争性 N 形式 Orange brown solid Hill配方 C₁₃H₈N₄OS 化学配方 C₁₃H₈N₄OS Molar Mass 268.3 可逆 N 结构配方图像 生物信息 主靶 PKR 主靶IC50 210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block 纯度 ≥90% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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