merck millipore,默克密理愽
  • merck millipore,默克密理博,171260,AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

  • merck millipore,默克密理博,171260,AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

    产品名称：AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
    产品型号：171260
    The AMPK Inhibitor, Compound C, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>

    merck millipore,默克密理博,171260,AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,171260,AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₅N₅O866405-64-3
    描述
    概述 A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
    产品目录编号 171260
    品牌系列 Calbiochem®
    同义词 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
    参考
    参考 Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
    Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
    Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
    Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
    Inoki, K., et al. 2003. Cell 115, 577.
    Fryer, L.G., 2002. FEBS Lett. 531, 189.
    Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
    产品信息
    CAS号 866405-64-3
    具有ATP竞争性 Y
    形式 Light yellow solid
    Hill配方 C₂₄H₂₅N₅O
    化学配方 C₂₄H₂₅N₅O
    Molar Mass 399.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 AMPK
    主靶IC50 25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
    主靶Ki EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, 100 mM HCl, or MeOH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,171260,AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,AB5735,Anti-Neurofilament M Antibody
下一件merck millipore产品：merck millipore,默克密理博,71571,pET-52 3C/LIC Vector Kit - Novagen


相关产品

merck millipore,默克密理博,ABN517,Anti-AIM2 Antibody merck millipore,默克密理博,ABN517,Anti-AIM2 Antibody

merck millipore,默克密理博,EZRL-83K,Rat Leptin ELISA merck millipore,默克密理博,EZRL-83K,Rat Leptin ELISA

merck millipore,默克密理博,14-691,MRCKα Protein, active, 10 µg merck millipore,默克密理博,14-691,MRCKα Protein, active, 10 µg

merck millipore,默克密理博,567442,Sodium Chloride Tablets - CAS 7647-14-5 - Calbiochem merck millipore,默克密理博,567442,Sodium Chloride Tablets - CAS 7647-14-5 - Calbiochem

merck millipore,默克密理博,AB5735,Anti-Neurofilament M Antibody merck millipore,默克密理博,AB5735,Anti-Neurofilament M Antibody

merck millipore,默克密理博,71571,pET-52 3C/LIC Vector Kit - Novagen merck millipore,默克密理博,71571,pET-52 3C/LIC Vector Kit - Novagen

merck millipore,默克密理博,401215,Goat Anti-Mouse IgG, H&L Chain Specific Peroxidase Conjugate merck millipore,默克密理博,401215,Goat Anti-Mouse IgG, H&L Chain Specific Peroxidase Conjugate

merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46 merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

merck millipore,默克密理博,07-108,Anti-Histone H4 Antibody merck millipore,默克密理博,07-108,Anti-Histone H4 Antibody

merck millipore,默克密理博,527450,PKR Inhibitor - CAS 608512-97-6 - Calbiochem merck millipore,默克密理博,527450,PKR Inhibitor - CAS 608512-97-6 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部