merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

  • merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

    产品名称：Anti-RPA2 p34 Antibody, clone RPA20 1-46
    产品型号：04-1481
    Anti-RPA2 p34 Antibody, clone RPA20 1-46 is a Mouse Monoclonal Antibody for detection of RPA2 p34 also known as Replication factor A protein 2 & has been validated in WB.

    merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

  • 产品介绍
  • merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1481
    描述 Anti-RPA2 p34 Antibody, clone RPA20 1-46
    Alternate Names
    • RPA32.
    • RF-A protein 2
    • RP-A p32
    • RP-A p34
    • Replication factor A protein 2
    • replication protein A2 (32kD)
    • replication protein A2, 32kDa
    • Replication protein A 32kDa subunit
    • RF-A, replication factor-A protein 2
    • p32
    • p34
    • RPA2
    • REPA2
    背景信息 RPA is a heterotrimeric protein complex that binds specifically to single-stranded DNA (ssDNA). It is composed of three subunits, RPA1 (70 kDa), RPA2 (32 kDa), and RPA3 (14 kDa), and plays multiple roles in DNA metabolism. RPA is required for DNA replication initiation, as well as replication elongation. At the onset of DNA replication, RPA is loaded onto chromatin after the binding of Cdc45 to origins. RPA is needed for subsequent loading of DNA polymerase and other replication proteins to initiate DNA replication. After DNA replication begins, RPA moves with replication forks, stabilizing ssDNA and assisting in DNA synthesis. In addition to its replication function, RPA is also known to play essential roles in damage repair and recombination.The 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK. Alternate names for RPA32 include replication protein A 32 kDa subunit, RP-A, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, and RPA32.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-RPA2 p34 Antibody, clone RPA20 1-46 is a Mouse Monoclonal Antibody for detection of RPA2 p34 also known as Replication factor A protein 2 & has been validated in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot (SNAP ID) Analysis: 0.5 µg/mL from a previous lot detected RPA2 on 10 µg of NIH/3T3 cell lysate.
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human RPA2.
    表位 Unknown
    克隆 RPA20, 1-46
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes RPA2.
    同种型 IgG1κ
    品种反应性 MouseHuman
    Species Reactivity Note Proven to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002946
    基因符号
    • RPA34
    • RPA2
    • REPA2
    • RPA32
    纯化方法 Protein G purfied
    UniProt编号
    • P15927
    UniProt汇总 FUNCTION: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.

    SUBUNIT STRUCTURE: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.

    SUBCELLULAR LOCATION: Nucleus. Note: Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.

    PTM: Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected RPA2 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-1481,Anti-RPA2 p34 Antibody, clone RPA20 1-46

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下一件merck millipore产品：merck millipore,默克密理博,07-108,Anti-Histone H4 Antibody


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