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merck millipore,默克密理博,526528,PIM-Kinase Inhibitor IX, SGI-1776 - Calbiochem
产品名称：PIM-Kinase Inhibitor IX, SGI-1776 - Calbiochem
产品型号：526528
The PIM-Kinase Inhibitor IX, SGI-1776 controls the biological activity of PIM-Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,526528,PIM-Kinase Inhibitor IX, SGI-1776 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₀H₂₂F₃N₅O • 2H₂SO₄ 描述 概述 A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10 µM). 产品目录编号 526528 品牌系列 Calbiochem®
同义词 N-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H₂SO₄ 参考 参考 Chen, L.S., et al. 2011. Blood 118, 693.
Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther. 8, 2882.
Chen, L.S., et al. 2009. Blood 114, 4150.产品信息 形式 Off-white powder Hill配方 C₂₀H₂₂F₃N₅O • 2H₂SO₄ 化学配方 C₂₀H₂₂F₃N₅O • 2H₂SO₄ Molar Mass 601.6 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,MAB8053F-KC,Anti-Adenovirus, FITC conjugated (1mL) KC
下一件merck millipore产品：merck millipore,默克密理博,4810-OP,OmniPur Glycine - CAS 56-40-6 - Calbiochem
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