merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1345,Anti-NLRP11 Antibody

  • merck millipore,默克密理博,06-1345,Anti-NLRP11 Antibody

    产品名称：Anti-NLRP11 Antibody
    产品型号：06-1345
    Detect NLRP11 using this Anti-NLRP11 Antibody validated for use in WB & IC.

    merck millipore,默克密理博,06-1345,Anti-NLRP11 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1345,Anti-NLRP11 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, R, MICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1345
    描述 Anti-NLRP11 Antibody
    Alternate Names
    • PYRIN-containing APAF1-like protein 6
    • NLR family, pyrin domain containing 11
    • NACHT, LRR and PYD domains-containing protein 11
    • PAAD- and NACHT-containing protein 10B
    • NACHT, leucine rich repeat and PYD containing 11
    • NACHT, LRR and PYD containing protein 11
    • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11
    • Nucleotide-binding oligomerization domain protein 17
    • PAAD-and NACHT domain-containing protein 10
    • PAAD- and NACHT-containing protein 10
    背景信息 NLRP11 is also known as NALP11 and is a member of the NALP family of cytoplasmic proteins. NALPs have been associated with activating caspase-1 using toll-like receptors (TLRs) during the immune response. NLRP11 has been linked to Crohn’s disease susceptibility.
    产品信息
    格式 Affinity Purified
    控制
    • PC12 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect NLRP11 using this Anti-NLRP11 Antibody validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected NLRP11 in NIH/3T3 cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human NLRP11 at the NACHT domain.
    表位 NACHT domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes NLRP11 at the NACHT domain.
    品种反应性 HumanRatMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_659444
    Entrez基因汇总 Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM].
    基因符号
    • PYPAF7
    • NLRP11
    • NALP1
    • PAN10
    • PYPAF6
    • NOD17
    纯化方法 Affinity purified
    UniProt编号
    • P59045
    UniProt汇总 FUNCTION: Involved in inflammation (Potential).

    SEQUENCE SIMILARITIES: Belongs to the NLRP family.

    Contains 1 DAPIN domain.

    Contains 6 LRR (leucine-rich) repeats.

    Contains 1 NACHT domain.

    SEQUENCE CAUTION: The sequence BAC03490.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in PC12 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected NLRP11 on 10 µg of PC12 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1345,Anti-NLRP11 Antibody

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