merck millipore,默克密理愽
  • merck millipore,默克密理博,07-507,Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody

  • merck millipore,默克密理博,07-507,Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody

    产品名称：Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody
    产品型号：07-507
    This Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody is validated for use in WB for the detection of phospho-BMK1/Erk5 (Thr218/Tyr220).

    merck millipore,默克密理博,07-507,Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-507,Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    B, H, M, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-507
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody
    产品信息
    格式 Affinity Purified
    控制
    • Sorbitol-treated HeLa cells
    演示 Affinity purified immunoglobulin in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 This Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody is validated for use in WB for the detection of phospho-BMK1/Erk5 (Thr218/Tyr220).
    主要应用
    • Western Blotting
    应用说明 Peptide Inhibition Analysis:
    HeLa cell lysate, HeLa cell lysate+ non-phosphorylated protein, and HeLa cell lysate + phosphorylated peptide were probed with Cat. No. 07-507, Anti-phospho-BMK 1/ERK5 (Thr218/Tyr220) (1µg/mL(1:1000) dilution). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminesence detection system.

    Arrow indicates BMK1/ERK5 (~115 kDa) on HeLa cell lysate & HeLa cell lysate + non-phosphorylated peptide. No band is present on the HeLa cell lysate + phosphorylated peptide indicating successful peptide inhibition of the antibody.
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 213-224 of human BMK1/Erk5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes phospho-BMK1/Erk5 (Thr218, Tyr220).
    同种型 IgG
    品种反应性 BovineHumanMouseRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_139033
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
    基因符号
    • PRKM7
    • MAPK7
    • ERK5
    • BMK1
    • ERK-5
    • ERK4
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q13164
    UniProt汇总 FUNCTION: SwissProt: Q13164 # MEK5 and ERK5 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.
    COFACTOR: Magnesium (By similarity).
    SIZE: 815 amino acids; 88637 Da
    TISSUE SPECIFICITY: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
    DOMAIN:SwissProt: Q13164 The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. & The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    PTM: Dually phosphorylated on Thr-218 and Tyr-220, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blotting/Peptide Inhibition Analysis in HeLa cell lysate.

    Western Blot/Peptide Inhibition Analysis: A 1:1,000 dilution of this antibody detected phospho-BMK1/Erk5 (Thr218/Tyr220) in HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2-8°C from date of shipment.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-507,Anti-phospho-BMK1/Erk5 (Thr218/Tyr220) Antibody

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