merck millipore,默克密理愽
  • merck millipore,默克密理博,04-214,Anti-c-Kit Antibody, CT, rabbit monoclonal

  • merck millipore,默克密理博,04-214,Anti-c-Kit Antibody, CT, rabbit monoclonal

    产品名称：Anti-c-Kit Antibody, CT, rabbit monoclonal
    产品型号：04-214
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect c-Kit using this Anti-c-Kit Antibody, CT, rab More>>

    merck millipore,默克密理博,04-214,Anti-c-Kit Antibody, CT, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-214,Anti-c-Kit Antibody, CT, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 04-214
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-c-Kit Antibody, CT, rabbit monoclonal
    Alternate Names
    • KIT, CD117, PBT, SCFR, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    • KIT
    • CD117
    • PBT
    • SCFR
    产品信息
    格式 Culture Supernatant
    演示 100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect c-Kit using this Anti-c-Kit Antibody, CT, rabbit validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 A synthetic peptide corresponding to residues in the C-terminus (cytoplasmic domain) of human c-Kit.
    表位 C-terminus
    宿主 Rabbit
    特异性 The C-terminal region of c-Kit.
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000222
    Entrez基因汇总 This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • c-kit
    • KIT
    • C-Kit
    • PBT
    • CD117
    • SCFR
    UniProt编号
    • P10721
    UniProt汇总 FUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
    SIZE: 976 amino acids; 109865 Da
    SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
    SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-214,Anti-c-Kit Antibody, CT, rabbit monoclonal

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