merck millipore,默克密理博,444152,MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4

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merck millipore,默克密理博,444152,MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4 - Calbiochem
产品名称：MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4 - Calbiochem
产品型号：444152
The MDM2 Antagonist IV, Nutlin-3a, also referenced under CAS 675576-98-4, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.

merck millipore,默克密理博,444152,MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4 - Calbiochem

产品介绍

merck millipore,默克密理博,444152,MDM2 Antagonist IV, Nutlin-3a - CAS 675576-98-4 - Calbiochem

重要规格表

经验配方	CAS号
C₃₀H₃₀Cl₂N₄O	675576-98-4

描述
概述	A cell-permeable and highly potent active enantiomer of Nutlin-3 (Cat. No. 444143) that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC₅₀ = 90 nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53^+/+MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment.
产品目录编号	444152
品牌系列	Calbiochem®
同义词	(-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one

参考
参考	Ohnstad, H.O., et al. 2011. BMC Cancer 11, 211. Shen, H. and Maki, C.G., 2010. J. Biol. Chem. 285, 23105. Kawamura, T., et al. 2009. Nature 460, 1140. Kojima, K., et al. 2006. Blood 108, 993. Laurie, N.A., et al. 2006. Nature 444, 61. Tovar, C., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1888. Vassilev, L.T. 2006. Trends Mol Med. 13, 23. Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844.

参考

Ohnstad, H.O., et al. 2011. BMC Cancer 11, 211.
Shen, H. and Maki, C.G., 2010. J. Biol. Chem. 285, 23105.
Kawamura, T., et al. 2009. Nature 460, 1140.
Kojima, K., et al. 2006. Blood 108, 993.
Laurie, N.A., et al. 2006. Nature 444, 61.
Tovar, C., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1888.
Vassilev, L.T. 2006. Trends Mol Med. 13, 23.
Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.

产品信息
CAS号	675576-98-4
形式	White powder
Hill配方	C₃₀H₃₀Cl₂N₄O
化学配方	C₃₀H₃₀Cl₂N₄O
Molar Mass	581.5
结构配方图像

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.