merck millipore,默克密理愽
  • merck millipore,默克密理博,526524,PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

  • merck millipore,默克密理博,526524,PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

    产品名称：PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem
    产品型号：526524
    The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>

    merck millipore,默克密理博,526524,PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,526524,PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₃NO₃S587852-28-6
    描述
    概述 A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
    产品目录编号 526524
    品牌系列 Calbiochem®
    同义词 (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a
    参考
    参考 Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
    产品信息
    CAS号 587852-28-6
    形式 Yellow solid
    Hill配方 C₁₃H₁₃NO₃S
    化学配方 C₁₃H₁₃NO₃S
    Molar Mass 263.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,526524,PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

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