merck millipore,默克密理愽
  • merck millipore,默克密理博,14-467,PDGFRα Protein, active, 50 µg

  • merck millipore,默克密理博,14-467,PDGFRα Protein, active, 50 µg

    产品名称：PDGFRα Protein, active, 50 µg
    产品型号：14-467
    Active, recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag, for use in Kinase Assays.

    merck millipore,默克密理博,14-467,PDGFRα Protein, active, 50 µg

  • 产品介绍
  • merck millipore,默克密理博,14-467,PDGFRα Protein, active, 50 µg

    描述
    产品目录编号 14-467
    品牌系列 Upstate
    商名
    • Upstate
    描述 PDGFRα Protein, active, 50 µg
    概述 Recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag
    应用
    应用 Active, recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006206.3
    Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
    基因符号
    • CD140A
    • PDGFRA
    • CD140a
    • PDGF-R-alpha
    • MGC74795
    • PDGFR2
    • Rhe-PDGFRA
    蛋白靶 PDGFRα
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P16234
    UniProt汇总 FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    SIZE: 1089 amino acids; 122670 Da
    SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
    SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 50 µg
    包装 Also available in 250μg size, please inquire for pricing and availability.

    merck millipore,默克密理博,14-467,PDGFRα Protein, active, 50 µg

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