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merck millipore,默克密理博,505763,ProRS Inhibitor, Halofuginone - CAS 64924-67-0 - Calbiochem
产品名称：ProRS Inhibitor, Halofuginone - CAS 64924-67-0 - Calbiochem
产品型号：505763
A cell-permeable racemic mixture of Halofuginone that inhibits of prolyl-tRNA synthetase.
merck millipore,默克密理博,505763,ProRS Inhibitor, Halofuginone - CAS 64924-67-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₇BrClN₃O₃•HBr 64924-67-0 描述 概述 A cell-permeable racemic mixture of Halofuginone whose D-(+)/(2R, 3S) enantiomer serves as the active inhibitor against ProRS-mediated aminoacylation by simultaneously preventing ProRS-catalyzed Pro-AMP formation and the subsequent Pro transfer from Pro-AMP to tRNAPro. Proline, but not other NEAA, is able to reverse the inhibitory effect of HF in in vitro rabbit reticulocyte lysate translations (1 µM HF; 1 mM Pro) and prevent HF-induced cellular AAR pathway activation (100 nM HF/2 mM Pro/MEF; 10 nM HF/1 mM Pro/Murine CD4+ CD25- T cells). Shown to inhibit bFGF-induced neovascularization in a murine corneal angiogenesis model (5 mg/kg/d via food intake) and significantly reduce the severity of MOG33-55-induced EAE in mice (2 µg/mouse/d i.p.) in vivo. Unlike AA-AMP mimetics, HF does not compete against ATP for ProRS binding. 产品目录编号 505763 品牌系列 Calbiochem®
同义词 STENOROL, HF, Hydrobromide, prolyl-tRNA synthetase Inhibitor, trans-(±)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide 参考 参考 Zhou, H., et al. 2013, Nature 494, 121.
Keller, T.L., et al. 2012, Nat. Chem. Biol. 12, 311.
Sundrud, M.S., et al. 2009, Science 324, 1334.
Elkin, M., et al. 2000, FASEB J. 14, 2477.
Elkin, M., et al. 1999, Clin. Cancer Res. 5, 1982.产品信息 CAS号 64924-67-0 形式 White powder Hill配方 C₁₆H₁₇BrClN₃O₃•HBr 化学配方 C₁₆H₁₇BrClN₃O₃•HBr 结构配方图像 生物信息 主靶 prolyl-tRNA synthetase 主靶IC50 18 nM 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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