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merck millipore,默克密理博,171263,AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem
产品名称：AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem
产品型号：171263
The AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,171263,AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₁₉N₃O₃S 280112-24-5 描述 概述 A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260). 产品目录编号 171263 品牌系列 Calbiochem®
同义词 4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide 应用数据 
参考 参考 Lemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206. 产品信息 CAS号 280112-24-5 形式 Off-white solid Hill配方 C₁₈H₁₉N₃O₃S 化学配方 C₁₈H₁₉N₃O₃S Molar Mass 357.43 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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