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描述 概述 Full-length, recombinant, human PTEN (GenBank target symbol = PTEN, ACC No. BC_005821) fused at N-terminus to a His•Tag® and S•Tag™ sequences and expressed in S. frugiperda insect cells. PTEN is a tumor suppressor that is frequently found mutated in human cancers. It serves as a lipid phosphatase and negative regulator of the PI-3K/Akt pathway. Absence of functional PTEN results in constitutive activation of Akt and mTOR kinases. 产品目录编号 481409 品牌系列 Calbiochem®
同义词 Phosphatase and Tensin Homolog Deleted on Chromosome 10 参考 参考 Harrington, L.S., et al. 2005. Trends Biochem. Sci. 30, 35.
Osaki, M., et al. 2004. Apoptosis 9, 667.
Lennon, G., et al. 1996. Genomics 33, 151.产品信息 形式 Liquid 配方 In 150 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 1 mM EDTA, 50% glycerol, pH 7.5. Molar Mass 53000 生物信息 纯度 ≥80% by SDS-PAGE 特异活性 ≥75 U/mg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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