merck millipore,默克密理愽
  • merck millipore,默克密理博,420130,JNK Inhibitor III, Cell-Permeable - Calbiochem

  • merck millipore,默克密理博,420130,JNK Inhibitor III, Cell-Permeable - Calbiochem

    产品名称：JNK Inhibitor III, Cell-Permeable - Calbiochem
    产品型号：420130
    The JNK Inhibitor III, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,420130,JNK Inhibitor III, Cell-Permeable - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420130,JNK Inhibitor III, Cell-Permeable - Calbiochem

    重要规格表

    经验配方
    C₁₉₁H₃₃₆N₇₀O₄₈S
    描述
    概述 A cell-permeable 37-mer peptide constructed by fusing human c-Jun δ domain (amino acids 33-57) sequence with that of HIV-TAT protein transduction domain (amino acids 47-57) via a γ-aminobutyric acid (GABA) spacer. Shown to specifically disrupt c-Jun/JNK complex formation and the subsequent phosphorylation and activation of c-Jun by JNK both in vitro and in intact cells. Since its mode of inhibition is different than that of JNK Inhibitor II (SP600125; Cat. No. 420119), these two inhibitors can complement each other in JNK signaling pathway studies.
    产品目录编号 420130
    品牌系列 Calbiochem®
    同义词 SAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
    参考
    参考 Holzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized white solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₉₁H₃₃₆N₇₀O₄₈S
    化学配方 C₁₉₁H₃₃₆N₇₀O₄₈S
    Molar Mass 4413.3
    吸湿 Hygroscopic
    肽序列 Ac-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
    可逆 N
    生物信息
    主靶 JNK
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or Acetic Acid
    肽序列 Ac-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420130,JNK Inhibitor III, Cell-Permeable - Calbiochem

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