merck millipore,默克密理愽
  • merck millipore,默克密理博,324377,Donepezil Hydrochloride - Calbiochem

  • merck millipore,默克密理博,324377,Donepezil Hydrochloride - Calbiochem

    产品名称：Donepezil Hydrochloride - Calbiochem
    产品型号：324377
    A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC₅₀ = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase.

    merck millipore,默克密理博,324377,Donepezil Hydrochloride - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324377,Donepezil Hydrochloride - Calbiochem

    重要规格表

    经验配方
    C₂₄H₂₉NO₃HCl
    描述
    概述 A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC50 = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase. In vivo, there is a marked and significant increase in acetylcholine content in rat cerebral cortex at a p.o. dose of 5 mg/kg. Furthermore, it inhibits brain cholinesterase (ChE) dose-dependently (ID50 = 2.6 mg/kg) without any marked adverse effects on ChE in the heart and small intestine. In a clinical trial, it has been shown to reduce AChE activity by 63.7% for the 5mg/d group and 77.3% for the 10mg/d group in Alzheimer's disease patients. Its off-target effects are indicated with the reversibly of inhibited voltage-gated K+/Na+ channels.
    产品目录编号 324377
    品牌系列 Calbiochem®
    同义词 E2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride
    参考
    参考 Yu, B., et al. 2005. Eur J Pharm 508, 15.
    Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
    Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
    Rogers, S., et al. 1998. Neurology 50, 136.
    产品信息
    形式 White solid
    Hill配方 C₂₄H₂₉NO₃HCl
    化学配方 C₂₄H₂₉NO₃HCl
    Molar Mass 415.95
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324377,Donepezil Hydrochloride - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,07-2274,Anti-FSP1/S100A4 Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB9332-200UL,Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain


相关产品

merck millipore,默克密理博,481409,PTEN, His•Tag and S•Tag™, Human Recombinant, S. frugiperda merck millipore,默克密理博,481409,PTEN, His•Tag and S•Tag™, Human Recombinant, S. frugiperda

merck millipore,默克密理博,16-282,Anti-Phosphotyrosine Antibody, clone 4G10, Magnetic Bead Conjugate merck millipore,默克密理博,16-282,Anti-Phosphotyrosine Antibody, clone 4G10, Magnetic Bead Conjugate

merck millipore,默克密理博,14-731M,CaM Kinase Iδ Protein, active, 250 µg merck millipore,默克密理博,14-731M,CaM Kinase Iδ Protein, active, 250 µg

merck millipore,默克密理博,ELI-004-M,IL-4 ELISPOT Antibody Pair, Mouse merck millipore,默克密理博,ELI-004-M,IL-4 ELISPOT Antibody Pair, Mouse

merck millipore,默克密理博,07-2274,Anti-FSP1/S100A4 Antibody merck millipore,默克密理博,07-2274,Anti-FSP1/S100A4 Antibody

merck millipore,默克密理博,AB9332-200UL,Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain merck millipore,默克密理博,AB9332-200UL,Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain

merck millipore,默克密理博,525295,PhosphoDetect™ Anti-Phosphotyrosine Mouse mAb (PY20) merck millipore,默克密理博,525295,PhosphoDetect™ Anti-Phosphotyrosine Mouse mAb (PY20)

merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2 merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

merck millipore,默克密理博,AB5566,Anti-Capsaicin Receptor Antibody, CT merck millipore,默克密理博,AB5566,Anti-Capsaicin Receptor Antibody, CT

merck millipore,默克密理博,MABF535,Anti-CD127 (IL-7Ra) Antibody (mouse), APC, clone A7R34 merck millipore,默克密理博,MABF535,Anti-CD127 (IL-7Ra) Antibody (mouse), APC, clone A7R34


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部