merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

  • merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

    产品名称：Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2
    产品型号：MAB1059
    Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2 is an antibody against Pigment Epithelium Derived Factor for use in ELISA, IC, IH & WB.

    merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

  • 产品介绍
  • merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, ELISA, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1059
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2
    Alternate Names
    • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin,pigment epithelium derived factor), member 1
    • pigment epithelium-derived factor
    • proliferation-inducing protein 35
    • serine (or cysteine) proteinase inhibitor, clade F (alpha-2<br />antiplasmin, pigment epithelium derived factor), member 1
    • clade F (alpha-2<br />antiplasmin
    • pigment epithelium derived factor)
    • member 1
    • serpin peptidase inhibitor
    背景信息 Pigment epithelium-derived factor (PEDF) was first identified as a 50 kDa secreted protein in conditioned medium from cultured fetal human retinal pigment epithelium (RPE) cells (Tombran-Tink, 1991). More recently, PEDF was shown to have neurotrophic activity in the retina in vivo (Cayouette, 1999). PEDF is also a neurotrophic and neuroprotective factor in other systems, including cultured cerebellar granule cells, primary hippocampal neurons, spinal cord motor neurons and amphibian photoreceptors cultured in the absence of RPE cells (Karakousis, 2001). The binding of PEDF to retinoblastoma and cerebellar granule cells may be receptor-mediated. Recently, PEDF was shown to be a potent inhibitor of angiogenesis in endothelial cell cultures and in rat cornea and retina in vivo (Dawson, 1999; Stellmach, 2001).
    产品信息
    格式 Purified
    控制
    • Eye tissue.
    演示 Purified mouse monoclonal IgG2a in buffer containing 0.02 M PBS, pH 7.6, 0.25 M NaCl with 0.1% sodium azide.
    应用
    应用 Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2 is an antibody against Pigment Epithelium Derived Factor for use in ELISA, IC, IH & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western Blot:
    Recognizes a protein with a molecular weight of ~46 kDa when tested against immunogen. Western blot positive control is available (Catalog number AG672)

    ELISA:
    A previous lot of this antibody was used on ELISA.

    Immunocytochemistry:
    A previous lot of this antibody was used on Immunocytochemistry.

    Immunohistochemistry:
    A previous lot of this antibody was used on frozen sections.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant human GST-PEDF fusion protein. The sequence corresponding to amino
    acids 196-347 of human PEDF tagged with GST on the N-terminal was expressed in E. Coli. GST-PEDF is about 46 kDa on SDS-PAGE.
    克隆 10F12.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes Pigment-Epithelium Derived Factor (PEDF).
    同种型 IgG2a
    品种反应性 RatHuman
    Species Reactivity Note Human. Expected to react with rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002615.4
    基因符号
    • PIG35
    • SERPINF1
    • Serpin-F1
    • EPC-1
    • PEDF
    纯化方法 Protein A purfied
    UniProt编号
    • P36955
    UniProt汇总 FUNCTION: SwissProt: P36955 # Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
    SIZE: 418 amino acids; 46342 Da
    SUBCELLULAR LOCATION: Secreted. Melanosome. Note=Enriched in stage I melanosomes.
    TISSUE SPECIFICITY: Retinal pigment epithelial cells and blood plasma.
    DEVELOPMENTAL STAGE: Expressed in quiescent cells.
    DOMAIN: SwissProt: P36955 The N-terminal (AA 44-121) exhibits neurite outgrowth- inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
    PTM: The N-terminus is blocked.
    SIMILARITY: Belongs to the serpin family
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on human placenta lysate.

    Western Blot Analysis:
    1:1000 dilution of this lot detected pigment epithelium on 10 μg of human placenta lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1059,Anti-Pigment Epithelium Derived Factor Antibody, clone 10F12.2

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