merck millipore,默克密理愽
  • merck millipore,默克密理博,480420,NF449 - CAS 389142-38-5 - Calbiochem

  • merck millipore,默克密理博,480420,NF449 - CAS 389142-38-5 - Calbiochem

    产品名称：NF449 - CAS 389142-38-5 - Calbiochem
    产品型号：480420
    A potent Gsα-subunit-selective G-protein antagonist.

    merck millipore,默克密理博,480420,NF449 - CAS 389142-38-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,480420,NF449 - CAS 389142-38-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₄₁H₂₄N₆O₂₉S₈ · 8Na389142-38-5
    描述
    概述 A potent Gsα-subunit-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s-subunit (IC50 = 140 nM) but not to Giα-1-subunit. Inhibits stimulation of adenylate cyclase activity in S49 cyc- cells (which lack endogenous Gsα-subunit) by exogenously added Gsα-subunit. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM).
    产品目录编号 480420
    品牌系列 Calbiochem®
    同义词 4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
    参考
    参考 Hulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
    Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
    产品信息
    CAS号 389142-38-5
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₄₁H₂₄N₆O₂₉S₈ · 8Na
    化学配方 C₄₁H₂₄N₆O₂₉S₈ · 8Na
    Molar Mass 1505.1
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 Gsα-subunit-selective G-protein antagonist
    主靶IC50 140 nM suppressing the rate of GTPγS binding to Gsα-s-subunit
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 dH₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,480420,NF449 - CAS 389142-38-5 - Calbiochem

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